Reporter：Matthew K. Waldor ，Professor of Medicine at Harvard Medical School
Topic：Creation of a New Cholera Vaccine
Location：Library Reporting Hall
I will discuss our studies on Vibrio cholerae, the cholera pathogen, and how knowledge gained from investigation of the evolution of virulent V. cholerae led to our engineering
a new live-attenuated cholera vaccine. Testing of the vaccine in an animal model revealed that it can provide protection from cholera even before it elicits an immune response.
Rapid protection required viable vaccine and suggesting a probiotic-like mechanism. The vaccine also stimulates adaptive immunity eliciting protective antibodies. Collectively, our
studies suggest that it may be possible to create a new generation of vaccines that work both in a probiotic-like fashion, providing extremely rapid protection from disease, as well as
In traditional manner triggering long-lived protective immune responses.
Dr. Waldor is Edward H. Kass Professor of Medicine at Harvard Medical School and a physician in the Division of Infectious Diseases at Brigham and Women's Hospital, Boston. He isprincipal investigator of HHMI, fellow of AMS and AAAS. He is awarded as Thousand Talents by China government. Dr. Waldor is reviewer of PNAS, Science, Cell, Nature and many top journals in microbiological field. He also words as editorial board of PLoS Biology, PloS Genetics and Current Opinion in Microbiology. Waldor’s lab investigates fundamental and translational questions related to human enteric pathogensincluding Vibrio cholerae, Vibrio parahaemolyticus, Shiga toxin producing E. coli (EHEC), Listeria monocytogenes and Shigella. The overarching goal of the laboratory is to enhance understanding of pathogen-host interactions, particularly in the context of animal models relevant to human infection. He has published more than 200 papers in enteropahtogenic microganism field, including 20 CNS papers. The H-index is 54.